Contract Research Portfolio SMC Laboratories model ‘STAM™’ is widely used in NASH research, with more than 40 papers (publications) and 80 international conferences (presentations) published using data from our STAM™ model so far.

SMC Laboratories’ Contracted Business Focused on Nonclinical CRO Portfolio

NAFLD / NASH ・NASH-HCC: STAM™ Model
・Fatty Liver / NAFLD: MCD Model
・Fatty Liver / NAFLD: ob / ob Model
Inflammation and Fibrosis IPF: Bleomycin-induced lung fibrosis model
COPD: Porcine Pancreatic Elastase (PPE) model
Liver cirrhosis: CCl4-induced liver fibrosis model
Cholestatic liver disease: Bile duct ligation (BDL) model
CKD: UUO-induced kidney fibrosis model
Adriamycin-induced nephropathy model
IBD: DSS-induced colitis model
Alzheimer’s disease: icv-STV model
Systemic sclerosis: Bleomycin-induced skin fibrosis model

Histopathology and Imaging Services

Processing and Embedding ・Embedding of human and animal tissues in paraffin (FFPE blocks) from fixed tissues.
・Embedding of human and animal tissues in O.C.T. (frozen O.C.T. embedded tissues) from fixed tissues.
・Instruction in preparing fresh frozen blocks for frozen sections. Sectioning ・Cutting of 4-8 μm thick sections from paraffin- and OCT-embedded blocks.
・Preparation of serial thin sections. Routine Staining.
・HE, Sirius Red, Masson’s trichrome, PAS, Oil Red, etc. Reporting We can perform evaluations in a variety of disease models.

Immunohistochemistry (IHC) Inflammation-related molecules, fibrosis-related molecules, etc.
・Functional Immunohistochemistry (double / multiple staining).
・Optimization and validation of new antibody staining protocols. Image Analysis ・Area, length, diameter, stained cand ell count, percentage of positive area, and shape, etc.
・Proliferation, apoptosis, pathological grading, etc. Results Interpretation Discussion of histological findings from a pharmacological perspective.